Recombinant Human GDNF Protein(Trx Tag)
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- 表达系统： E.coli
- 蛋白编码： P39905
| 别称 |
Astrocyte derived trophic factor;Astrocyte derived trophic factor 1;Astrocyte-derived trophic factor;ATF 1;ATF 2;Atf;ATF1;ATF2;gdnf;GDNF;Glial cell derived neurotrophic factor;Glial Cell Line Derived Neurotrophic Factor;Glial cell line-derived neurotrophic factor;Glial derived neurotrophic factor;HFB1 GDNF;hGDNF;HSCR3
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| 表达系统 |
E.coli
|
| 序列 |
Arg109-Ile211
|
| 蛋白编码 |
P39905
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| 种属 |
human
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| 计算分子量 |
31.2 kDa
|
| 表观分子量 |
31 kDa
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| 标签 |
N-Trx
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 90% as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 10 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.
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实验操作视频
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