Recombinant Human GFRRA2 Protein ((Fc & His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： O00451
| 别称 |
GDNF Family Receptor Alpha-2;GDNF Receptor Alpha-2;GDNF Receptor Beta;GDNFR-Alpha-2;GDNFR-Beta;GDNFRB;GFR-Alpha-2;GFRA2;NRTNR-Alpha;NTNR-Alpha;Neurturin Receptor Alpha;RET Ligand 2;RETL2;TGF-Beta-Related Neurotrophic Factor Receptor 2;TRNR2
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ser22-Ser441
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| 蛋白编码 |
O00451
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| 种属 |
Human
|
| 计算分子量 |
74.7 kDa
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| 表观分子量 |
120 kDa
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| 标签 |
C-Fc-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
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实验操作视频
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