Recombinant Human HER2/ErbB2 Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P04626
| 别称 |
CD340;ENV;ENVW;ERBB2;ERVWE1;HER-2;HER-2/neu;HER2;HERV-7q;HERV-W-ENV;HERV7Q;HERVW;HERVWENV;MLN 1;MLN19;Metastatic lymph node gene 19 protein;NGL;Proto-oncogene Neu;Receptor tyrosine-protein kinase erbB-2;TKR1;Tyrosine kinase-type cell surface receptor HER2
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| 表达系统 |
HEK293 Cells
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| 序列 |
Thr 23-Thr652
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| 蛋白编码 |
P04626
|
| 种属 |
Human
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| 计算分子量 |
96.5 kDa
|
| 表观分子量 |
120-145 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein; and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development; cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas; including breast; prostate; ovarian; lung cancers and so on. HER2 is activated by dimerization and not activated by EGF; TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR; ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
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实验操作视频
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