Recombinant Human HMGB1 protein(His Tag)
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- 表达系统： E.coli
- 蛋白编码： P09429
- 应用性： Cell culture
| 别称 |
HMG-1;HMG1;HMG3;SBP-1
|
| 表达系统 |
E.coli
|
| 序列 |
Met 1-Glu 215
|
| 蛋白编码 |
P09429
|
| 种属 |
Human
|
| 计算分子量 |
25.7 kDa
|
| 表观分子量 |
35 kDa
|
| 标签 |
C-His
|
| 生物活性 |
Measure by its ability to induce TNF alpha in RAW264.7 cells.The ED50 for this effect is <10 μg/mL.
|
| 纯度 |
> 98 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.1 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from sterile PBS,pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.
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实验操作视频
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