Recombinant Human HO1 Protein(Trx Tag)
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- 表达系统： E.coli
- 蛋白编码： P09601
| 别称 |
HSP;heme oxygenase;heme oxygenase (decycling);bK286B;HO-1 HMOX;HMOX1;HMOX1D;HO-1;HSP32;bK286B10;32 kD;D8Wsu38e;heat shock protein 32 kD;heat shock protein 32kD;Hemox;Hmox;HMOX 1;HO 1;HO-1 HMOX1;heme oxygenase (decycling) 1;heme oxygenase 1;heat shock protein;32-kD;HO;HO1;bK286B10;heme oxygenase 1;HMOX1D;HO-1;HSP32
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| 表达系统 |
E.coli
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| 序列 |
Met1-Thr261
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| 蛋白编码 |
P09601
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| 种属 |
Human
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| 计算分子量 |
48.7 kDa
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| 表观分子量 |
48 kDa
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| 标签 |
N-Trx
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 10 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
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| 背景 |
Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
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实验操作视频
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