Recombinant Human ICOS Ligand/ICOSL Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： O75144
| 别称 |
B7 Homolog 2;B7-H2;B7-Like Protein Gl50;B7-Related Protein 1;B7H2;B7RP-1;B7RP1;CD275;ICOS Ligand;ICOSL;ICOSLG;KIAA0653
|
| 表达系统 |
HEK293 Cells
|
| 序列 |
Asp19-Ser258
|
| 蛋白编码 |
O75144
|
| 种属 |
Human
|
| 计算分子量 |
27.7 kDa
|
| 表观分子量 |
40-70 kDa
|
| 标签 |
C-His
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.2.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Inducible Co-Stimulator Ligand (ICOSLG) belongs to the immunoglobulin superfamily. ICOSLG contains Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. ICOSLG acts as a costimulatory signal for T-cell proliferation and cytokine secretion, it also induces B-cell proliferation and differentiation into plasma cells. It could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. ICOSLG is widely expressed lymph nodes, leukocytes and spleen, detected on activated monocytes and dendritic cells.
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实验操作视频
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