Recombinant Human IGF-1/IGF1 Protein (aa 52-118)
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- 表达系统： E.coli
- 蛋白编码： P05019
- 应用性： Cell culture
| 别称 |
IBP1;IGF-I;IGF1;Insulin-Like Growth Factor I;MGF;Mechano Growth Factor;Somatomedin-C
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| 表达系统 |
E.coli
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| 序列 |
Thr52-Ala118
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| 蛋白编码 |
P05019
|
| 种属 |
Human
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| 计算分子量 |
7.3 kDa
|
| 表观分子量 |
9 kDa
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| 标签 |
None
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| 生物活性 |
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is 20-100 ng/ml.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.5 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM NaAc-HAc, pH 4.5
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R; IGF-2R; and the insulin receptor and plays a key role in cell cycle progression; cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.
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实验操作视频
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