IMD;MGC;CTLA;CANDF;CDw;IL17RA;CANDF5;CD217;CDw217;IL-17RA;IL17R;IMD51;hIL-17R;CD127;CD217 antigen;CDW127;CTLA8;HIL 17R;hIL17R;I17RA;IL 17 receptor;IL 17 receptor A;IL 17RA;IL17;IL-17 R alpha;IL-17 receptor A;IL17A receptor;IL-17R;IL17R-A;IL17-RA;IL-17R-alpha;IL7RA;ILRA;Interleukin 17 receptor A;Interleukin-17 receptor A;MGC10262;CDw217;Interleukin-17 receptor A

Mammalian

Leu33-Trp320

Q96F46

Human

31.6 kDa

50-65 kDa

C-His

Not validated for activity

> 95% as determined by reducing SDS-PAGE.

< 1.0 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.