Recombinant Human IL4RA/CD124 Protein (mFc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P24394
| 别称 |
582J;IL4R;CD124;IL-4RA;IL4RA;IL-4 receptor subunit alpha;IL-4-binding protein;IL4-BP;IL-4R subunit alpha;IL-4R-alpha;Interleukin-4 receptor subunit alpha;582J2.1;IL-4RαIL 4R alpha;IL4R nirs variant 1;IL4RA;Interleukin 4 receptor;Interleukin 4 receptor alpha chain;sIL4Ralpha/prot;Soluble IL-4 receptor subunit alpha;Soluble IL-4R-alpha;Soluble interleukin-4 receptor subunit alpha
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| 表达系统 |
HEK293 Cells
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| 序列 |
Met26-Gln231
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| 蛋白编码 |
P24394
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| 种属 |
Human
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| 计算分子量 |
50.2 kDa
|
| 表观分子量 |
65-86 kDa
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| 标签 |
C-mFc
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a cytokine binding region and one fibronectin type III domain; a 24 aa transmembrane segment; and a 569 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif. IL4-Ra plays an important role in Th2-biased immune responses; alternative macrophage activation; mucosal immunity; allergic inflammation; tumor progression; and atherogenesis. Soluble forms of IL4-Ra; generated by alternate splicing or proteolysis; retain ligand binding properties and inhibit IL-4 bioactivity.
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实验操作视频
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