Recombinant Human IL-12 Receptor Subunit Beta1/IL-12RB1/CD212 (C-6His)
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- 表达系统： HEK293 Cells
- 蛋白编码： P42701
| 别称 |
IMD;IL-12R-BETA;IL12RB1;CD212;IL-12R-BETA1;IL12RB;IMD30;IL12R;IL-12Rb1;CD212 antigen;IL-12 receptor beta component;IL-12 receptor subunit beta-1;IL-12R subunit beta-1;IL-12R-beta-1;interleukin-12 receptor beta-1 chain;interleukin-12 receptor subunit beta-1
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| 表达系统 |
HEK293 Cells
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| 序列 |
Cys24-Glu540
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| 蛋白编码 |
P42701
|
| 种属 |
Human
|
| 计算分子量 |
58.1 kDa
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| 表观分子量 |
80-110 kDa
|
| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.
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实验操作视频
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