Recombinant Human IL-23 Protein(Fc Tag)
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- 表达系统： Mammalian
- 蛋白编码： Q9NPF7
| 别称 |
UNQ;PRO;IL-23;IL-23A;IL23A;SGRF;UNQ2498;PRO5798
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| 表达系统 |
Mammalian
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| 序列 |
Arg20-Pro189
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| 蛋白编码 |
Q9NPF7
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| 种属 |
Human
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| 计算分子量 |
43.6 kDa
|
| 表观分子量 |
45 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 90% as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU/mg of the protein as determined by the LAL method
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
IL-23 , which is mainly secreted by antigen-presenting cells , is a member of the IL-12 family , which includes IL-12 , IL-27 , and IL-35. IL-23 is a heterodimeric cytokine , comprised of a unique p19 subunit and p4 subunit , the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1 , the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation , expansion , and survival by binding to its receptor , thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases , such as autoimmune arthritis , primary biliary cirrhosis , and inflammatory bowel disease.
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实验操作视频
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