Recombinant Human IL-24 protein(His Tag)
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- 表达系统： E.coli
- 蛋白编码： Q13007
- 应用性： Cell culture
| 别称 |
MDA;MOB;Melanoma Differentiation Association Protein;IL24;C49A;FISP;IL10B;MDA7;MOB5;ST16;MDA-7 (Melanoma Differentiation-Associated gene 7 protein);Melanoma Differentiation Association Protein 7;IL 24;IL 4 induced secreted protein;IL-24;interleukin 24;Interleukin-24;MDA-7;Melanocyte associated Mda 7;Melanoma differentiation-associated gene 7 protein;Suppression of tumorigenicity 16;Suppression of tumorigenicity 16 (melanoma differentiation);Suppression of tumorigenicity 16 protein
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| 表达系统 |
E.coli
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| 序列 |
Gln 52-Leu 206
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| 蛋白编码 |
Q13007
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| 种属 |
Human
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| 计算分子量 |
19.1 kDa
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| 表观分子量 |
17 kDa
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| 标签 |
C-His
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| 生物活性 |
Measure by its ability to chemoattract BaF3 cells transfected with human IL-20R alpha and IL-20R beta. The ED50 for this effect is <120 pg/mL.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 0.1 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from sterile PBS,pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2.
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实验操作视频
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