Recombinant Human IL-3 Receptor Subunit Alpha/IL-3RA/CD123 (C-6His)
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- 表达系统： HEK293 Cells
- 蛋白编码： P26951
| 别称 |
IL3RA;CD123;IL3R;IL3RAY;IL3RX;IL3RY;hIL-3Ra;IL-3 Receptor alpha;IL-3 receptor subunit alpha;IL-3R subunit alpha;IL-3R subunitalpha;IL-3RA;IL-3R-alpha;IL-3Receptoralpha;IL-3Rα;IL-4Receptoralpha;IL-5Receptoralpha;IL-6Receptoralpha;IL-7Receptoralpha;Interleukin-3 receptor subunit alpha;IL-3R&alpha
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| 表达系统 |
HEK293 Cells
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| 序列 |
Thr19-Arg305
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| 蛋白编码 |
P26951
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| 种属 |
Human
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| 计算分子量 |
33.9 kDa
|
| 表观分子量 |
40-60 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
CD123, also known as Interleukin-3 receptor subunit alpha, belongs to the type I cytokine receptor family. In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage‑committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL‑3 with low affinity. The beta subunit does not bind IL‑3 by itself but is required for the high‑affinity binding of IL‑3 to the heterodimeric receptor complex.
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实验操作视频
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