Recombinant Human Interleukin-36 alpha/IL-36 alpha
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- 表达系统： E.coli
- 蛋白编码： Q9UHA7
- 应用性： Cell culture
| 别称 |
FIL;IL1F;Interleukin-1 Family Member;IL-1F;IL36A;FIL1;FIL1(EPSILON);FIL1E;IL-1F6;IL1(EPSILON);IL1F6;FIL1 Epsilon;IL-1 Epsilon;Interleukin-1 Epsilon;Interleukin-1 Family Member 6;Interleukin-36 Alpha;IL1E;IL 1 epsilon;IL 1F6;IL 1H1;IL1RP2;Interleukin 1 epsilon;Interleukin 1 family member 6;Interleukin 1 family member 6 (epsilon);Interleukin 36 alpha;MGC129552;MGC129553;MGC151479;MGC151481;OTTMUSP00000012798;RP23-176J12.4
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| 表达系统 |
E.coli
|
| 序列 |
Lys6-Phe158
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| 蛋白编码 |
Q9UHA7
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| 种属 |
Human
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| 计算分子量 |
18.1 kDa
|
| 表观分子量 |
17 kDa
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| 标签 |
C-His
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| 生物活性 |
Measure by its ability to induce IL-8 secretion in human PBMCs.The ED50 for this effect is <0.7 ng/mL.
|
| 纯度 |
> 98 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.1 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from sterile PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
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实验操作视频
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