Recombinant Human LAG3/CD223 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P18627
- 应用性： BLI
| 别称 |
CD223;LAG-3;LAG3;Lymphocyte activation gene 3 protein;Protein FDC
|
| 表达系统 |
HEK293 Cells
|
| 序列 |
Leu23-Gly434
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| 蛋白编码 |
P18627
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| 种属 |
Human
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| 计算分子量 |
45.5 kDa
|
| 表观分子量 |
60-80 kDa
|
| 标签 |
C-His
|
| 生物活性 |
Loaded Anti-Human LAG-3 mAb-Fc on Protein A Biosensor, can bind Human LAG-3-6His with an affinity constant of 0.46 nM as determined in BLI assay.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
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实验操作视频
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