Recombinant Human LILRB2/CD85d Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： AAH36827.1
| 别称 |
CD85 Antigen-Like Family Member D;CD85d;ILT;ILT-4;Immunoglobulin-Like Transcript 4;LILRB2;LIR-2;Leukocyte Immunoglobulin-Like Receptor 2;Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2;MIR-10;Monocyte/Macrophage Immunoglobulin-Like Receptor 10
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Gln22-His458
|
| 蛋白编码 |
AAH36827.1
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| 种属 |
Human
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| 计算分子量 |
48.6 kDa
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| 表观分子量 |
58-75 kDa
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| 标签 |
C-His
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
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实验操作视频
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