Recombinant Human Merlin/NF2 protein (His Tag)
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- 表达系统： E.coli
- 蛋白编码： P35240-1
| 别称 |
BANF;Bilateral acoustic neuroma;CAN;MERL_HUMAN;Merlin;Moesin ezrin radixin like protein;Moesin ezrin radizin like;Moesin-ezrin-radixin-like;NF 2;Neurofibromatosis 2;Neurofibromatosis type 2;Neurofibromatosis2;SCH;Schwannomerlin
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| 表达系统 |
E.coli
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| 序列 |
Met1-Leu595
|
| 蛋白编码 |
P35240-1
|
| 种属 |
Human
|
| 计算分子量 |
69.7 kDa
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| 表观分子量 |
68-71 kDa
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| 标签 |
N-His
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 90% as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 10 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
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实验操作视频
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