Recombinant Human MICA Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： AAH16929.1
- 应用性： ELISA
| 别称 |
MHC Class I Polypeptide-Related Sequence A;MIC-A;MICA;PERB11.1
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Glu24-Gln308
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| 蛋白编码 |
AAH16929.1
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| 种属 |
Human
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| 计算分子量 |
59.9 kDa
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| 表观分子量 |
85-110 kDa
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| 标签 |
C-Fc
|
| 生物活性 |
Immobilized Mouse NKG2D at 2 μg/ml (100 μl/well) can bind Human MICA (C-Fc). The EC50 of Human MICA (C-Fc) is ≤10 ng/ml.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.
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实验操作视频
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