Recombinant Human MMP1 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P03956
| 别称 |
CLG;Fibroblast Collagenase;Interstitial Collagenase;MMP-1;MMP1;Matrix Metalloproteinase-1
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Phe20-Asn469
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| 蛋白编码 |
P03956
|
| 种属 |
Human
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| 计算分子量 |
52.9 kDa
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| 表观分子量 |
56 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 2mM CaCl2, 1mM DTT, 0.05%Brij35, 10% Glycerol, pH 5.0.
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| 复溶方法 |
Not Applicable
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| 背景 |
Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP1 contains several distinct domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin like) domain. MMP-1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, α1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL1, IGFBP3, IGFBP5, pro-MMP2, and pro-MMP9. A significant role of MMP1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into 3/4, 1/4 fragments. MMP1 may also be involved in enzyme cascades, cytokine regulation and cell surface molecule modulation.
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实验操作视频
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