Recombinant Human PCSK9 Protein (D374Y, His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： Q8NBP7
- 应用性： ELISA
| 别称 |
NARC-1;NARC1;Neural Apoptosis-Regulated Convertase 1;PC9;PCSK9;Proprotein Convertase 9;Proprotein Convertase Subtilisin/Kexin Type 9;Subtilisin/Kexin-Like Protease PC9
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| 表达系统 |
HEK293 Cells
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| 序列 |
Gln31-Gln692(Asp374Tyr,Val474Ile,Gly504Arg,Gly670Glu)
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| 蛋白编码 |
Q8NBP7
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| 种属 |
Human
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| 计算分子量 |
15-18&60-80 kDa
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| 表观分子量 |
13.8&58.2 kDa
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| 标签 |
C-His
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| 生物活性 |
Immobilized Recombinant Human LDL R (C-Fc) at 5μg/ml (100 μl/well) can bind Recombinant Human PCSK9 . The ED50 of Recombinant Human PCSK9 is 39.17 ng/ml.
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| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (D374Y) is a gain of function mutant of human PCSK9 protein. Human PCSK9 is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain are secreted together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and it plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
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实验操作视频
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