Recombinant Human PD-L1 Protein(Sumo Tag)
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- 表达系统： E.coli
- 蛋白编码： Q9NZQ7
| 别称 |
PDL;B7H;PD-L;PD1L;Programmed cell death 1 ligand;PDCD1L;PDCD1LG;B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274;B7-H1;B7 homolog 1;CD274 molecule;PDCD1 ligand 1;Programmed death ligand 1;PD1L1;Programmed cell death 1 ligand 1;PDL1;PD-L1;B7-H;B7H1;CD274 molecule;PDCD1L1;PDCD1LG1;B7 H;B7 H1;CD 274;CD274 antigen;MGC142294;MGC142296;OTTHUMP00000021029;PD L1;PDL 1;RGD1566211
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| 表达系统 |
E.coli
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| 序列 |
Phe19-Arg238
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| 蛋白编码 |
Q9NZQ7
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| 种属 |
Human
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| 计算分子量 |
37.1 kDa
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| 表观分子量 |
43 kDa
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| 标签 |
N-Sumo
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 85% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 10 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
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| 背景 |
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
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实验操作视频
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