Recombinant Human PSMA Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： Q04609
| 别称 |
Cell growth-inhibiting gene 27 protein;FGCP;FOLH;FOLH1;Folate hydrolase 1;GCP2;GCPII;Glutamate carboxypeptidase 2;Mgcp;NAALAD1;NAALADase I;NAALAdase;PSM;PSMA;mGCP
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| 表达系统 |
HEK293 Cells
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| 序列 |
Lys44-Ala750
|
| 蛋白编码 |
Q04609
|
| 种属 |
Human
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| 计算分子量 |
80.6 kDa
|
| 表观分子量 |
90-120 kDa
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| 标签 |
N-His
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 5% Trehalose, pH 5.5.
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| 复溶方法 |
Not Applicable
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| 背景 |
Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.
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实验操作视频
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