Recombinant Human PVRL2/Nectin-2/CD112 (C-6His-Avi) Biotinylated-Elabscience伊莱瑞特【官网】

Recombinant Human PVRL2/Nectin-2/CD112 (C-6His-Avi) Biotinylated

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货号：PKSH034032
说明书

说明书

Recombinant Human PVRL2/Nectin-2/CD112 (C-6His-Avi) Biotinylated

Price: ¥7560.00 ¥2786.00

Size:

100 μg 20 μg

表达系统： HEK293 Cells
蛋白编码： Q92692-2
应用性： ELISA

别称	CD112;HVEB;Herpes Virus Entry Mediator B;Herpesvirus Entry Mediator B;HveB;Nectin-2;PRR2;PVRL2;Poliovirus Receptor-Related Protein 2
表达系统	HEK293 Cells
序列	Gln32-Leu360
蛋白编码	Q92692-2
种属	Human
计算分子量	38.4 kDa
表观分子量	45-60 kDa
标签	C-His-Avi
生物活性	Immobilized Human PVRIG-mFc at 10μg/ml (100 μl/well) can bind Biotinylated Human Nectin-2-His-Avi. The ED50 of Biotinylated Human Nectin-2-His-Avi is 0.42 ug/ml.
纯度	> 95 % as determined by reducing SDS-PAGE.
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method.
保存条件	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输条件	This product is provided as lyophilized powder which is shipped with ice packs.
制剂	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
复溶方法	Please refer to the printed manual for detailed information.
背景	CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.

> 95 % as determined by reducing SDS-PAGE.

Immobilized Human PVRIG-mFc at 10μg/ml (100 μl/well) can bind Biotinylated Human Nectin-2-His-Avi. The ED50 of Biotinylated Human Nectin-2-His-Avi is 0.42 ug/ml.