Recombinant Human SMAD3 Protein (His & Flag Tag)
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- 表达系统： E.coli
- 蛋白编码： P84022
| 别称 |
JV15-2;MAD homolog 3;MADH3;Mad3;Mothers against DPP homolog 3;Mothers against decapentaplegic homolog 3;SMAD 3;SMAD family member 3;SMAD3;Smad3;hMAD-3;hSMAD3
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| 表达系统 |
E.coli
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| 序列 |
Ser2-Ser425
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| 蛋白编码 |
P84022
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| 种属 |
Human
|
| 计算分子量 |
50.5 kDa
|
| 表观分子量 |
50-60 kDa
|
| 标签 |
N-His-Flag
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 85 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, 2mM EDTA, pH 8.0.
|
| 复溶方法 |
Not Applicable
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| 背景 |
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. It also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.
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实验操作视频
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