Recombinant Human STING/TMEM173 Protein (Sumo & His Tag)
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- 表达系统： E.coli
- 蛋白编码： Q86WV6
| 别称 |
Mediator of IRF3 activation;Stimulator of interferon genes protein;TMEM173;sting
|
| 表达系统 |
E.coli
|
| 序列 |
Val155-Val341
|
| 蛋白编码 |
Q86WV6
|
| 种属 |
Human
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| 计算分子量 |
33.8 kDa
|
| 表观分子量 |
35 kDa
|
| 标签 |
N-SUMO-His
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 100mM NaCl, 10% Glycerol, pH8.0.
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| 复溶方法 |
Not Applicable
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| 背景 |
Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.
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实验操作视频
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