Recombinant Human TGFB1/TGF-beta 1 Protein
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- 表达系统： CHO Stable Cells
- 蛋白编码： P01137
- 应用性： Cell culture
| 别称 |
CED;DPD1;LAP;Latency-Associated Peptide;TGF-Beta-1;TGF-beta 1;TGFB;TGFB1;Transforming Growth Factor Beta-1
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| 表达系统 |
CHO Stable Cells
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| 序列 |
Ala279-Ser390
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| 蛋白编码 |
P01137
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| 种属 |
Human
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| 计算分子量 |
12.8 kDa
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| 表观分子量 |
13 kDa
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| 标签 |
None
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| 生物活性 |
Measured by its ability to inhibit the IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 4-40 pg/ml
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.01 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone; articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions; including the control of cell growth; cell proliferation; cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
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Use of Myriocin as co-adjuvant in glaucoma surgery: an in vitro study.
IF: 3.400Journal： INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2024)
实验操作视频
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