Recombinant Human TRAIL R2/TNFRSF10B Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： O14763
| 别称 |
CD262;DR5;Death Receptor 5;KILLER;TNF-Related Apoptosis-Inducing Ligand Receptor 2;TNFRSF10B;TRAIL Receptor 2;TRAIL-R2;TRAILR2;TRICK2;Tumor Necrosis Factor Receptor Superfamily Member 10B;ZTNFR9
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Ile56-Glu182
|
| 蛋白编码 |
O14763
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| 种属 |
Human
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| 计算分子量 |
15.3 kDa
|
| 表观分子量 |
16-22 kDa
|
| 标签 |
C-His
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
TNFRSF10B is a member of the TNF-receptor superfamily; and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L); and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types; and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region; followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
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实验操作视频
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