Recombinant Human TRAIL R3/TNFRSF10C Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： O14798
| 别称 |
Antagonist Decoy Receptor for TRAIL/Apo-2L;DcR1;Decoy Receptor 1;Decoy TRAIL Receptor Without Death Domain;Lymphocyte Inhibitor of TRAIL;TNF-Related Apoptosis-Inducing Ligand Receptor 3;TRAIL Receptor ;Tumor Necrosis Factor Receptor Superfamily Member 10C
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ala26-Ala221
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| 蛋白编码 |
O14798
|
| 种属 |
Human
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| 计算分子量 |
21.8 kDa
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| 表观分子量 |
38-58 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains; lacks the intracellular signaling domain. As a result; binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
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实验操作视频
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