Recombinant Mouse CD39/ENTPD1 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P55772
| 别称 |
CD39;Ecto-ATP diphosphohydrolase 1;Ecto-ATPDase 1;Ecto-ATPase 1;Ecto-apyrase;Ectonucleoside triphosphate diphosphohydrolase 1;Lymphoid cell activation antigen;NTPDase 1
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| 表达系统 |
HEK293 Cells
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| 序列 |
Thr38-Ile478
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| 蛋白编码 |
P55772
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| 种属 |
Mouse
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| 计算分子量 |
50.5 kDa
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| 表观分子量 |
60-90 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, pH 7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Ectonucleoside triphosphate diphosphohydrolase-1(NTPDase-1)is an integral membrane protein with an extracellular active site. Recombinant mouse NTPDase-1wasexpressed as a protein lacking its N- andC-terminaltransmembrane domains, resulting in the secretion of the soluble ectodomain. NTPDase-1was originally describedas CD39, a B lymphocyte cell surface marker. but it is also present on the surface of natural killer cells, T cells, and some endothelial cells. NTPDase1hydrolyzes the β-andγ phosphate residues of nucleotides, preferring ATP as the substrate. Through its hydrolysis of extracellular nucleotides, NTPDase-1plays arole in the regulation of purinergic signaling. NTPDase-1is involved in the processes of thromboregulation and vascular inflammation. The administration ofsoluble NTPDase-1may have therapeutic applications for the treatment of some vascular and transplantation-associateddiseases.
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实验操作视频
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