Recombinant Mouse CD40/TNFRSF5 Protein(His Tag)
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- 表达系统： Mammalian
- 蛋白编码： P27512
| 别称 |
IMD;B-cell surface antigen CD;Tumor necrosis factor receptor superfamily member;HIGM;Tnfrsf;HIGM1;I326936;IGM;IMD3;p50;T-BAM;TRAP;Bp50;CD40;Tnfrsf5;Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;CD40L receptor;gp39 R; TNFRSF5;CD40 (protein);CD40 molecule;CDW40
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| 表达系统 |
Mammalian
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| 序列 |
Leu20-Arg193
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| 蛋白编码 |
P27512
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| 种属 |
Mouse
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| 计算分子量 |
19 kDa
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| 表观分子量 |
30 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 90% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thoμght to be an early event in Alzheimer disease pathogenesis.
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实验操作视频
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