Recombinant Mouse Ctla4 Protein(His Tag)
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- 表达系统： Mammalian
- 蛋白编码： P09793
| 别称 |
ALPS5;CD 152;CD;CD152;CD152 antigen;CD152 isoform;Celiac disease 3;CELIAC3;CTLA 4;CTLA-4;CTLA4;CTLA4;Cytotoxic T cell associated 4;Cytotoxic T lymphocyte antigen 4;Cytotoxic T lymphocyte associated 4;Cytotoxic T lymphocyte associated 4;soluble isoform;included;Cytotoxic T lymphocyte associated antigen 4;Cytotoxic T lymphocyte associated antigen 4 short spliced form;Cytotoxic T lymphocyte associated protein 4;Cytotoxic T lymphocyte associated serine esterase 4;Cytotoxic T lymphocyte protein 4;Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;GRD4;GSE;ICOS;IDDM12;insulin-dependent diabetes mellitus 12;Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4;OTTHUMP00000216623
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| 表达系统 |
Mammalian
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| 序列 |
Glu36-Asp161
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| 蛋白编码 |
P09793
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| 种属 |
Mouse
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| 计算分子量 |
13.8 kDa
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| 表观分子量 |
20-30 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 90% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
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实验操作视频
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