CXCL;SCYB;Secretory protein N;Neutrophil-Activating Protein;GROα/CXCL;C-X-C Motif Chemokine 1;GRO-A;GRO-Alpha(1-73);Growth-Regulated Alpha Protein;GROα/CXCL1;Melanoma Growth Stimulatory Activity;NAP3;Neutrophil-Activating Protein 3;Platelet-derived growth factor-inducible protein KC;Secretory protein N51;CINC1;CINC-1;CXCL1;FSP;GRO1;GROa;KC;MGSA;MGSA-a;MGSA-alpha;NAP-3;SCYB1;GRO alpha;Growth Regulated Oncogene Alpha;Gro

E.coli

Ala25-Lys96

P12850

Mouse

27.9 kDa

28 kDa

N-Trx

Not validated for activity

> 95% as determined by reducing SDS-PAGE.

< 10 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.