Recombinant Mouse GITR/TNFRSF18 Protein(Fc Tag)
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- 表达系统： Mammalian
- 蛋白编码： O35714
| 别称 |
Tumor necrosis factor receptor superfamily member;Tnfrsf;AITR;CD357;GITR-D;Glucocorticoid-induced TNFR-related protein;Tumor necrosis factor receptor superfamily member 18;Gitr;Tnfrsf18; GITR; AITR
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| 表达系统 |
Mammalian
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| 序列 |
Gln20-His153
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| 蛋白编码 |
O35714
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| 种属 |
Mouse
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| 计算分子量 |
39.6 kDa
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| 表观分子量 |
50 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 90% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
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实验操作视频
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