Recombinant Mouse IL1R1/CD121a Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P13504
| 别称 |
D2S;Interleukin-1 receptor type;IL1-R;mIL-1R;CD121 antigen-like family member A;CD121a;CD121b;D2S1473;IL-1 RI;IL1R;Il1r-1;IL1-R1;IL-1R-1;IL-1R-alpha;IL-1RT1;IL-1RT-1;IL-iR;Interleukin-1 receptor alpha;Interleukin-1 receptor type 1;mIL-1R1;P80;Il-1r1;Il1ra;Il1r1;IL-1R type I;IL1R;Interleukin 1 receptor;interleukin 1 receptor type 1;mIL-1R1;type I
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| 表达系统 |
HEK293 Cells
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| 序列 |
Leu20-Lys338
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| 蛋白编码 |
P13504
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| 种属 |
Mouse
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| 计算分子量 |
64.0 kDa
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| 表观分子量 |
85-110 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Mouse Interleukin-1 receptor type 1/IL-1 RI is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1α or IL1βbut not IL1ra, was identified. This Type I receptor complex appears to mediate all the known IL1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL1 signals. In addition to the membranebound form of IL1 RII, a naturallyoccurring soluble form of IL1 RII has been described. It has been suggested that the Type II receptor, either as the membranebound or as the soluble form, serves as a decoy for IL1 and inhibits IL1 action by blocking the binding of IL1 to the signaling Type I receptor complex.
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实验操作视频
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