Recombinant Mouse IL1RL1/ST2 Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P14719-2
- 应用性： ELISA
| 别称 |
STE;DER;Fit;Protein T;Protein ST;Lymphocyte antigen;Interleukin-1 receptor-like;suppression of tumorigenicity;IL1RL;IL-1 R;IL-1RL;DER4;Fit-1;IL-1 R4;IL-1RL1;IL-33R;Interleukin-1 receptor-like 1;Lymphocyte antigen 84;Protein ST2;Protein T1;ST2L;ST2V;suppression of tumorigenicity 2;Ly84;St2;Ste2;Il1rl1
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ser27-Ala337(Val192Ala)
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| 蛋白编码 |
P14719-2
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| 种属 |
Mouse
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| 计算分子量 |
62.7 kDa
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| 表观分子量 |
90-110 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Immobilized Mouse IL-33(Cat: PKSM041090) at 5μg/ml(100 μl/well) can bind Mouse ST2-Fc. The ED50 of Mouse ST2-Fc is 0.25ug/ml.
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.
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实验操作视频
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