Recombinant Mouse Interleukin-12/IL-12 Protein
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- 表达系统： HEK293 Cells
- 蛋白编码： P43432&P43431
| 别称 |
CLMF p35;CLMF p40;Cytotoxic lymphocyte maturation factor 35 kDa subunit;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12;IL-12 subunit p35;IL-12 subunit p40;IL-12A;IL-12B;Interleukin 12;Interleukin-12 subunit alpha;Interleukin-12 subunit beta
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| 表达系统 |
HEK293 Cells
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| 序列 |
Met23-Ser335&Arg23-Ala215
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| 蛋白编码 |
P43432&P43431
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| 种属 |
Mouse
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| 计算分子量 |
35.8&21.7 kDa
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| 表观分子量 |
40-55&20-28 kDa
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| 标签 |
None
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.01 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Mouse IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on murine cells. It is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
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实验操作视频
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