Recombinant Mouse TGFβ1/TGFB1 Protein
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- 表达系统： HEK293 Cells
- 蛋白编码： P04202
- 应用性： Cell culture
| 别称 |
CED;CEDLAP;DPD1;TGF-b1;TGF-beta 1 protein;TGF-beta-1;TGFB;TGFB1;TGFbeta;latency-associated peptide;transforming growth factor beta-1
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ala279-Ser390
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| 蛋白编码 |
P04202
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| 种属 |
Mouse
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| 计算分子量 |
12.8 kDa
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| 表观分子量 |
13 kDa
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| 标签 |
None
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| 生物活性 |
Measured by its ability to inhibit IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 5-25 pg/ml.
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 0.01 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
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TGFβ1 Regulates Cellular Composition of In Vitro Cardiac Perivascular Niche Based on Cardiospheres
IF: 0.900Journal： BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2024)
实验操作视频
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