Recombinant Mouse TIMP2/TIMP-2 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P25785
| 别称 |
CSC-21Ktissue inhibitor of metalloproteinase 2;TIMP metalloproteinase inhibitor 2;TIMP-2;Tissue inhibitor of metalloproteinase 2.;metalloproteinase inhibitor 2
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| 表达系统 |
HEK293 Cells
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| 序列 |
Cys27-Pro220
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| 蛋白编码 |
P25785
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| 种属 |
Mouse
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| 计算分子量 |
22.5 kDa
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| 表观分子量 |
21 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP-1, TIMP-2, TIMP-3, and TIMP-4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.
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实验操作视频
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