Recombinant Rat CD80/B7-1 Protein (His Tag)

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- 表达系统: HEK293 Cells
- 蛋白编码: O35187
别称 |
Activation B7-1 antigen;B7;CD80 ;T-lymphocyte activation antigen CD80
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表达系统 |
HEK293 Cells
|
序列 |
Vla30-Gln248
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蛋白编码 |
O35187
|
种属 |
Rat
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计算分子量 |
25.7 kDa
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表观分子量 |
38-60 kDa
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标签 |
C-His
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生物活性 |
Not validated for activity
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纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 6% Trehalose,4% Mannitol, 0.05% Tween 80, pH7.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
复溶方法 |
Please refer to the printed manual for detailed information.
|
背景 |
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
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实验操作视频
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