ACE2 Polyclonal Antibody(Capture/Detector)
Price:
- 宿主： Rabbit
- 反应性： Rat
- 应用性： ELISA Capture/Detector
| Verified Samples |
Verified Samples in ELISA: Recombinant Rat ACE2 protein, Rat serum, Rat plasma |
| Dilution | ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Recombinant Rat ACE2 protein expressed by Mammalian |
| Abbre | ACE2 |
| Synonyms | ACEH, ACEII, |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular |
| Conjugation | Unconjugated |
| Background | ACE-2, also called ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE . Human ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 Mrna is found at high levels in testis, kidney, and heart and at moderate levels in colon, small intestine, and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity. Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo. |
