Active CASP3 Monoclonal Antibody（E-AB-22115）|-Elabscience伊莱瑞特【官网】

Active CASP3 Monoclonal Antibody

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货号：E-AB-22115
文献（25）
说明书

说明书

Price: ¥2310.00 ¥1420.00 ¥580.00

Size:

120 μL 60 μL 20 μL

宿主： Mouse
反应性： Human;Mouse;Rat
应用性： WB;IHC-p;IF

Verified Samples	Verified Samples in WB: Hela, 3T3, Rat brain Verified Samples in IHC: Human liver
Dilution	WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200
Clonality	Monoclonal
Isotype	IgG
Immunogen	Recombinant Protein
Abbre	Active Caspase-3
Synonyms	A830040C14Rik, Apopain, CASP-3, CASP3, CC3, CPP-32, CPP32, CPP32B, Casp3a, Caspase 3, Caspase-3 subunit p12, Cysteine p, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, apoptosis-related cysteine protease a
Swissprot	P42574
Observed MW	17 kDa
Cellular Localization	Cytoplasm.
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4.
Purification Method	Protein A purification
Research Areas	Cancer, Cell Biology, Metabolism, Neuroscience
Clone No.	5A2
Conjugation	Unconjugated
Background	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain with Active CASP3 Monoclonal Antibody

Immunohistochemistry of paraffin-embedded Human liver tissue using Active CASP3 Monoclonal Antibody at dilution of 1:200.

Asprosin improved neuronal survival by suppressing apoptosis and enhancing the activity of the autophagy pathway in the MCAO model in rats

IF: 3.3

Journal： European Review for Medical and Pharmacological Sciences (2024)

DOI：10.26355/eurrev_202403_35608

Reactivity：Rat

Sample Type：brain tissue
Comparative expression and localization of visfatin, chemerin, and chemerin receptor proteins in a heat-stressed mouse testis

IF: 2.7

Journal： TISSUE & CELL (2024)

DOI：10.1016/j.tice.2024.102374

Reactivity：Mouse

Sample Type：testis
Hederagenin Induces Apoptosis of Human Hepatoma HepG2 Cells via the Mitochondrial Pathway

IF: 1.6

Journal： COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2024)

DOI：10.2174/0113862073254353230925074944

Reactivity：Human
Phytosphingosine inhibits the growth of lung adenocarcinoma cells by inducing G2/M-phase arrest, apoptosis, and mitochondria-dependent pathway cell death in vitro and in vivo

IF: 5.1

Journal： CHEMICO-BIOLOGICAL INTERACTIONS (2023)

DOI：10.1016/j.cbi.2023.110795

PMID：37956922

Reactivity：Human
Cycas pectinata stimulates germ cell proliferation in mouse testes

IF: 4.400

Journal： PROCESS BIOCHEMISTRY (2023)

DOI：10.1016/j.procbio.2023.05.026

Reactivity：Mouse

Sample Type：testis
Pterostilbene-Isothiocyanate Inhibits Proliferation of Human MG-63 Osteosarcoma Cells via Abrogating β-Catenin/TCF-4 Interaction─A Mechanistic Insight

IF: 4.1

Journal： ACS Omega (2023)

DOI：10.1021/acsomega.3c02732

PMID：38027335

Reactivity：Human
Morphological and molecular changes in the Harderian gland of streptozotocin-induced diabetic rats

IF: 2.8

Journal： Journal of Experimental Zoology Part A-Ecological and Integrative Physiology (2023)

DOI：10.1002/jez.2741

PMID：37522474

Reactivity：Rat

Sample Type：Harderian gland (HG)
Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity

IF: 10.183

Journal： Molecular Therapy-Nucleic Acids (2022)

DOI：10.1016/j.omtn.2022.11.008

PMID：36514353

Reactivity：Human
First Evidence of the Expression and Localization of Prothymosin α in Human Testis and Its Involvement in Testicular Cancers

IF: 6.064

Journal： Biomolecules (2022)

DOI：10.3390/biom12091210

PMID：36139050

Reactivity：Human

Sample Type：testicular tissue
Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats

IF: 3.855

Journal： Current Molecular Pharmacology (2022)

DOI：10.2174/1874467215666220127115602

Reactivity：Rat

Sample Type：testicular tissue

E-AB-1001	Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1024	Goat Anti-Mouse IgG(H+L)(Biotin conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1011	Goat Anti-Mouse IgG(H+L)(Cyanine3 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1015	Goat Anti-Mouse IgG(H+L)(FITC conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1059	Goat Anti-Mouse IgG(H+L)(Elab Fluor® 594 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10 mL , 3 mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10 mL , 3 mL
E-AB-1076	Goat Anti-Mouse IgG(H+L)(Elab Fluor® 647 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1196	HRP-Goat Anti-Mouse IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL