Active CASP3 Monoclonal Antibody
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- 宿主： Mouse
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC-p;IF
| Verified Samples |
Verified Samples in WB: Hela, 3T3, Rat brain Verified Samples in IHC: Human liver |
| Dilution | WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200 |
| Clonality | Monoclonal |
| Isotype | IgG |
| Immunogen | Recombinant Protein |
| Abbre | Active Caspase-3 |
| Synonyms | A830040C14Rik, Apopain, CASP-3, CASP3, CC3, CPP-32, CPP32, CPP32B, Casp3a, Caspase 3, Caspase-3 subunit p12, Cysteine p, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, apoptosis-related cysteine protease a |
| Swissprot | |
| Observed MW | 17 kDa |
| Cellular Localization | Cytoplasm. |
| Tissue Specificity | Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Neuroscience |
| Clone No. | 5A2 |
| Conjugation | Unconjugated |
| Background | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. |
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Pterostilbene-Isothiocyanate Inhibits Proliferation of Human MG-63 Osteosarcoma Cells via Abrogating β-Catenin/TCF-4 Interaction─A Mechanistic Insight
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Morphological and molecular changes in the Harderian gland of streptozotocin-induced diabetic rats
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The petroleum ether extract of Brassica rapa L. induces apoptosis of lung adenocarcinoma cells via the mitochondria-dependent pathway
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Diabetes Induced Changes in the Expression of Markers for?Alveolar Epithelial Type I and II Cells in the Lung of the Albino Rat
IF: 0.444Journal： JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY (2021)Reactivity：RatSample Type：lung tissue -
Nigral and ventral tegmental area lesioning induces testicular and sperm morphological abnormalities in a rotenone model of Parkinson’s disease
IF: 3.292Journal： ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020)PMID：32439558Reactivity：RatSample Type：Tissue homogenate -
Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson’s disease
IF: 3.263 -
Cistanche tubulosa phenylethanoid glycosides induce apoptosis in Eca?109 cells via the mitochondria?dependent pathway
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