APC Anti-Mouse CD206/MMR Antibody[C068C2]
![APC Anti-Mouse CD206/MMR Antibody[C068C2]](http://files.elabscience.cn/assets/images/loading.png)
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- 应用性： FCM;ICFCM
- 亚型： Rat IgG2a, κ
- 宿主： Rat
| Alternate Names | MMR, MR, MRC1, macrophage mannose receptor, mannose receptor |
| Cellular Localization |
Membrane;Endosome
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| Clone No | |
| Isotype | Rat IgG2a, κ |
| Leadtime |
咨询
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| Background |
CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
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| Abbre | CD206 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype Control | |
| Applications | |
| Form | Liquid |
| Concentration | 5 μL/Test |
| Conjugation | APC |
| Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12个月 |
| Shipping |
冰袋 |
| Gene ID |
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IF: 15.800Journal： ACS Nano (2024)Reactivity：MouseSample Type：spleen tissue,peritoneal lavage fluid -
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IF: 14.300 -
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IF: 10.000 -
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IF: 8.700 -
Engineered Carrier-Free Nanosystem-Induced In Situ Therapeutic Vaccines for Potent Cancer Immunotherapy
IF: 8.300Journal： ACS Applied Materials & Interfaces (2024)Reactivity：MouseSample Type：4T1 cell-Xenograft -
PFDA promotes cancer metastasis through macrophage M2 polarization mediated by Wnt/β-catenin signaling
IF: 8.100 -
Adipocyte-specific FAK deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus
IF: 7.900
| E-CK-A105 | 10×ACK Lysis Buffer | 500mL , 200mL , 100mL |
| E-CK-A107 | Cell Staining Buffer | 500mL , 200mL , 100mL |
| E-CK-A109 | Intracellular Fixation/Permeabilization Buffer Kit | 500Assays , 100Assays , 50Assays |
