APC Anti-Mouse Foxp3 Antibody[3G3]
![APC Anti-Mouse Foxp3 Antibody[3G3]](http://files.elabscience.cn/assets/images/loading.png)
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- 应用性： ICFCM
- 亚型： Mouse IgG1, κ
- 宿主： Mouse
| Alternate Names | Forkhead box protein P3, Foxp3, IPEX, JM2 |
| Cellular Localization |
Nucleus
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| Clone No | |
| Isotype | Mouse IgG1, κ |
| Leadtime |
咨询
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| Background |
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
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| Abbre | Foxp3 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype Control | |
| Applications | |
| Form | Liquid |
| Concentration | 5 μL/Test |
| Conjugation | APC |
| Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12个月 |
| Shipping |
冰袋 |
| Gene ID |
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NIR-activated Janus nanomotors with promoted tumor permeability for synergistic photo-immunotherapy
IF: 9.400Journal： Acta Biomaterialia (2024)Reactivity：MouseSample Type：spleen tissue -
Engineered Carrier-Free Nanosystem-Induced In Situ Therapeutic Vaccines for Potent Cancer Immunotherapy
IF: 8.300Journal： ACS Applied Materials & Interfaces (2024)Reactivity：MouseSample Type：4T1 cell-Xenograft -
Paclitaxel combined with Compound K inducing pyroptosis of non-small cell lung cancer cells by regulating Treg/Th17 balance
IF: 5.300 -
Matrine Ameliorates DSS-Induced Colitis by Suppressing Inflammation, Modulating Oxidative Stress and Remodeling the Gut Microbiota
IF: 4.900Journal： INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)Reactivity：MouseSample Type：Mesenteric lymph nodes (MLNs),Peyer’s patches (PPs) -
HP inulin-MCT dietary fiber improves lipid metabolism and prevents non-alcoholic steatohepatitis in obese mice
IF: 3.800 -
Preclinical study of TLR stimulation combined PD-1 antibody enhance the therapeutic effect of microwave ablation on NSCLC
IF: 2.800 -
Multifunctional nanoadjuvant-driven microenvironment modulation for enhanced photothermal immunotherapy in breast cancer
IF: 10.800Journal： JOURNAL OF CONTROLLED RELEASE (2023)PMID：37634552Reactivity：MouseSample Type：4T1 cell-xenograft -
A Trojan Horse Delivery Vehicle Carrying siRNA Nanotherapeutics with Multiple Tumor Microenvironment Responsiveness Elicits Robust Antitumor Immune Responses In Situ via a “Self-Synergistic” Approach
IF: 10.000
| E-CK-A105 | 10×ACK Lysis Buffer | 500mL , 200mL , 100mL |
| E-CK-A107 | Cell Staining Buffer | 500mL , 200mL , 100mL |
| E-CK-A108 | Foxp3/Transcription Factor Staining Kit | 20Assays |
