APC Anti-Mouse IL-17A Antibody[TC11-18H10.1]
![APC Anti-Mouse IL-17A Antibody[TC11-18H10.1]](http://files.elabscience.cn/assets/images/loading.png)
Price:
- 应用性： ICFCM
- 亚型： Rat IgG1, κ
- 宿主： Rat
| Alternate Names | CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, Interleukin-17A |
| Cellular Localization |
Secreted
|
| Clone No | |
| Isotype | Rat IgG1, κ |
| Leadtime |
咨询
|
| Background |
IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
|
| Abbre | IL-17A |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype Control | |
| Applications | |
| Form | Liquid |
| Concentration | 5 μL/Test |
| Conjugation | APC |
| Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12个月 |
| Shipping |
冰袋 |
| Gene ID |
-
Paclitaxel combined with Compound K inducing pyroptosis of non-small cell lung cancer cells by regulating Treg/Th17 balance
IF: 5.300 -
Double-Negative T Cells Promote Liver Fibrosis Progression by Regulating Treg/Th17
IF: 3.200Journal： JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2024)Reactivity：MouseSample Type：peripheral blood,liver tissue,spleen tissue -
Repurposing TAK875 as a novel STAT3 inhibitor for treating inflammatory bowel disease
IF: 5.800 -
Moxibustion regulates T-regulatory/T-helper 17 cell balance by modulating the microRNA-221/suppressor of cytokine signaling 3 axis in a mouse model of rheumatoid arthritis
IF: 3.034
| E-CK-A091 | Cell Stimulation and Protein Transport Inhibitor Kit | 500Assays , 200Assays , 100Assays , 50Assays |
| E-CK-A105 | 10×ACK Lysis Buffer | 500mL , 200mL , 100mL |
| E-CK-A107 | Cell Staining Buffer | 500mL , 200mL , 100mL |
| E-CK-A109 | Intracellular Fixation/Permeabilization Buffer Kit | 500Assays , 100Assays , 50Assays |
