APC Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]
![APC Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]](http://files.elabscience.cn/assets/images/loading.png)
Price:
- 应用性： ICFCM
- 亚型： Rat IgG2a, κ
- 宿主： Rat
| Alternate Names | IPEXJM2ScurfinZinc finger protein JM2, Forkhead box protein P3 |
| Cellular Localization |
Nucleus;Cytoplasm
|
| Clone No | |
| Isotype | Rat IgG2a, κ |
| Leadtime |
咨询
|
| Background |
FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4<sup>+</sup>/CD25<sup>-</sup> cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.
|
| Abbre | Foxp3 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse;Rat |
| Clonality | Monoclonal |
| Isotype Control | |
| Applications | |
| Form | Liquid |
| Conjugation | APC |
| Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12个月 |
| Shipping |
冰袋 |
| Gene ID |
-
Engineered Carrier-Free Nanosystem-Induced In Situ Therapeutic Vaccines for Potent Cancer Immunotherapy
IF: 8.300Journal： ACS Applied Materials & Interfaces (2024)Reactivity：MouseSample Type：4T1 cell-Xenograft -
Preclinical study of TLR stimulation combined PD-1 antibody enhance the therapeutic effect of microwave ablation on NSCLC
IF: 2.800 -
Multifunctional nanoadjuvant-driven microenvironment modulation for enhanced photothermal immunotherapy in breast cancer
IF: 10.800Journal： JOURNAL OF CONTROLLED RELEASE (2023)PMID：37634552Reactivity：MouseSample Type：4T1 cell-xenograft -
A Trojan Horse Delivery Vehicle Carrying siRNA Nanotherapeutics with Multiple Tumor Microenvironment Responsiveness Elicits Robust Antitumor Immune Responses In Situ via a “Self-Synergistic” Approach
IF: 10.000
| E-CK-A105 | 10×ACK Lysis Buffer | 500mL , 200mL , 100mL |
| E-CK-A107 | Cell Staining Buffer | 500mL , 200mL , 100mL |
| E-CK-A108 | Foxp3/Transcription Factor Staining Kit | 20Assays |
