Biotin Anti-Human CD74 Antibody[LN2]-Elabscience伊莱瑞特【官网】

Biotin Anti-Human CD74 Antibody[LN2]

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货号：E-AB-F1072B
说明书

说明书

Price: ¥1200.00 ¥480.00

Size:

100μg 25μg

应用性： FCM
亚型： Mouse IgG1, κ
宿主： Mouse

Alternate Names	CD74, DHLAG, HLA class II histocompatibility antigen gamma chain, Ia antigen-associated invariant chain, Ii, p33
Cellular Localization	Membrane
Clone No	LN2
Isotype	Mouse IgG1, κ
Leadtime	咨询
Background	CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
Abbre	CD74
Swissprot	P04233
Host	Mouse
Reactivity	Human
Clonality	Monoclonal
Isotype Control	Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Applications	FCM
Form	Liquid
Concentration	0.5 mg/mL
Conjugation	Biotin
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Storage	This product can be stored at 2-8°C for 12 months. Do not freeze.
Expiration Date	12个月
Shipping	冰袋
Gene ID	972