Caspase-9 Monoclonal Antibody
Price:
Size:
100 μL
25 μL
- 宿主： Mouse
- 反应性： Human
- 应用性： WB
| Verified Samples |
Verified Samples in WB: Hep G2, HeLa, THP-1 |
| Dilution | WB 1:250-1:500 |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Immunogen | Recombinant Human Caspase-9 protein expressed by E.coli |
| Abbre | Caspase-9 |
| Synonyms | Apoptosis related cysteine peptidase, Apoptotic protease-activating factor 3, Caspase 9 apoptosis related cysteine peptidase, Caspase 9 Dominant Negative, Caspase 9c, Caspase-9 subunit p10, ICE LAP6, ICE like apoptotic protease 6, ICE-like apoptotic protease 6, protein phosphatase 1, regulatory subunit 56, RNCASP9, MCH, Apoptotic protease Mch, PPP1R, ICE-LAP, CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, caspase-9, Caspase 9, CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3 (APAF-3), ICE-like apoptotic protease 6 (ICE-LAP6) |
| Swissprot | |
| Calculated MW | 46 kDa |
| Observed MW | 35 kDa;47 kDa |
| Cellular Localization | Cytoplasm, Nucleus, Mitochondrion |
| Tissue Specificity | Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Protein A/G Purification |
| Research Areas | Cell Biology, Cancer, Metabolism |
| Clone No. | 3B6 |
| Conjugation | Unconjugated |
| Background | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). |
Western blot with Anti Caspase-9 Monoclonal antibody at dilution of 1:500. Lane 1: Hep G2 cell lysate, Lane 2: HeLa cell lysate, Lane 3: THP-1 cell lysate.
积分商城
微信公众号
