FITC Anti-Mouse CD206/MMR Antibody[C068C2]（E-AB-F1135C）|-Elabscience伊莱瑞特【官网】

FITC Anti-Mouse CD206/MMR Antibody[C068C2]

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货号：E-AB-F1135C
文献（34）
说明书

说明书

FITC Anti-Mouse CD206/MMR Antibody[C068C2]

Price: ¥1440.00 ¥1080.00 ¥2280.00

Size:

100 Tests 50 Tests 100 Tests × 2

应用性： FCM;ICFCM
亚型： Rat IgG2a, κ
宿主： Rat

流式标记抗体&同型对照抗体特惠65折（不含流式纯抗）

2025-08-19 ~ 2025-09-30

Alternate Names	MMR, MR, MRC1, macrophage mannose receptor, mannose receptor
Cellular Localization	Membrane;Endosome
Clone No	C068C2
Isotype	Rat IgG2a, κ
Leadtime	咨询
Background	CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
Abbre	CD206
Swissprot	Q61830
Host	Rat
Reactivity	Mouse
Clonality	Monoclonal
Isotype Control	FITC Rat IgG2a, κ Isotype Control[2A3]
Applications	FCM;ICFCM
Form	Liquid
Concentration	5 μL/Test
Conjugation	FITC
Conjugation Information	FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).
Spectrum
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration Date	12个月
Shipping	冰袋
Gene ID	17533

C57BL/6 murine abdominal macrophages elicited by starch broth are stained with APC Anti-Mouse F4/80 Antibody and FITC Anti-Mouse CD206 Antibody (Left). Abdominal macrophages are stained with APC Anti-Mouse F4/80 Antibody and FITC Rat IgG2a, κ Isotype Control (Right).

Poldip2 Aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway

IF: 5.2

Journal： LIFE SCIENCES (2025)

DOI：10.1016/j.lfs.2025.123681

Reactivity：Mouse
OTUD4-mediated inhibition of YAP1 signaling pathway in ovarian cancer: Implications for macrophage polarization and recruitment

IF: 4.8

Journal： INTERNATIONAL IMMUNOPHARMACOLOGY (2025)

DOI：10.1016/j.intimp.2024.114011

Reactivity：Human
Macrophage Membrane-Cloaked ROS-Responsive Albumin Nanoplatforms for Targeted Delivery of Curcumin to Alleviate Acute Liver Injury

IF: 4.5

Journal： MOLECULAR PHARMACEUTICS (2025)

DOI：10.1021/acs.molpharmaceut.4c00808

Reactivity：Mouse
Diffuse large B-cell lymphoma cell-derived exosomal NSUN2 stabilizes PDL1 to promote tumor immune escape and M2 macrophage polarization in a YBX1-dependent manner

IF: 3.8

Journal： ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2025)

DOI：10.1016/j.abb.2025.110322

Reactivity：Human
Cationic liposomes encapsulating IL-2 selectively induce apoptosis and significantly reduce the secretion of cytokines on M1-murine polarized macrophages

IF: 3.7

Journal： CYTOKINE (2025)

DOI：10.1016/j.cyto.2025.156903

Reactivity：Mouse
Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo-immunotherapy

IF: 14.7

Journal： Nature Communications (2024)

DOI：10.1038/s41467-024-50020-w

Reactivity：Mouse

Sample Type：CT26 cell-Xenograft,lymph node(LNDs)
In situ reprogramming of tumor-associated macrophages enhances cancer immunotherapy

IF: 13.2

Journal： Nano Today (2024)

DOI：10.1016/j.nantod.2024.102420

Reactivity：Mouse

Sample Type：CT26 cell-Xenograft
Enhancing myocardial infarction treatment through bionic hydrogel-mediated spatial combination therapy via mtDNA-STING crosstalk modulation

IF: 10.5

Journal： JOURNAL OF CONTROLLED RELEASE (2024)

DOI：10.1016/j.jconrel.2024.06.015

Reactivity：Rat
A POSS-Based Metal-Phenolic Network with Coupled Hardness and Softness for Photodynamic-Immunotherapy of Triple-Negative Breast Cancer

IF: 9.6

Journal： ACS Materials Letters (2024)

DOI：10.1021/acsmaterialslett.4c00661

Reactivity：Mouse

Sample Type：4T1 cell-Xenograft
A multifunctional composite nanoparticle with antibacterial activities, anti-inflammatory, and angiogenesis for diabetic wound healing

IF: 7.7

Journal： INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

DOI：10.1016/j.ijbiomac.2024.129531

Reactivity：Human

E-CK-A105	10×ACK Lysis Buffer	500 mL , 200 mL , 100 mL
E-CK-A107	Cell Staining Buffer	500 mL , 200 mL , 100 mL
E-CK-A109	Intracellular Fixation/Permeabilization Buffer Kit	500 Assays , 100 Assays , 50 Assays

Q11:IHC实验，想知道抗原修复条件是什么？是用EDTA还是枸橼酸钾？

修复条件一般为高温高压或者微波加热修复。
例如：抗原修复（高压法）：压力锅中加入足以淹没切片的 10 mmol/ml 的枸橼酸盐缓冲液（pH 6.0）（配制：将抗原修复液溶于相应体积 ddH2O中，混匀），加热至沸腾，切片置耐热塑料切片架上，放入锅中，盖好锅盖，扣上压力阀，继续加热，设置保压 4 min，时间到后打开放气阀放气，压力归零后开锅盖将内锅取出放置室温冷却，待溶液冷却至室温后取出切片（约30 min）。
抗原修复（微波法）：烧杯中加入足以淹没切片的 10 mmol/ml 的枸橼酸盐缓冲液（pH 6.0）（配制：将抗原修复液溶于相应体积 ddH2O中，混匀），加热至沸腾，切片置耐热塑料切片架上，放入烧杯中，中小火加热30min后取出，放置室温冷却，待溶液冷却至室温后取出切片（约30 min）。
IHC修复液的选择建议参考抗体使用说明书，或者参考以下方案：人体样本，优先推荐使用pH9.0的EDTA修复液（临床样本）；大/小鼠样本，优先推荐使用pH6.0的枸橼酸修复液（科研样本）。

Q12:IHC在数据表上是什么意思？是冷冻切片吗？与IHC-F区别？

IHC是免疫组化实验，使用的切片一般包含有IHC-P（石蜡切片）和IHC-F（冰冻切片）两种。