HO1/HMOX1 Polyclonal Antibody
Price:
- 宿主： Rabbit
- 反应性： Human;Mouse
- 应用性： WB;IHC;ELISA Capture/Detector
| Verified Samples |
Verified Samples in WB: A549, NIH-3T3 Verified Samples in IHC: Human breast cancer Verified Samples in ELISA: Recombinant Human HO1/HMOX1 protein, Human serum, Human plasma |
| Dilution | WB 1:500-1:1000, IHC 1:500-1:1000, ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Recombinant Human HO1/HMOX1 protein expressed by E.coli |
| Abbre | HO1/HMOX1 |
| Synonyms | Heme oxygenase 1, HO-1, HMOX1, HO, HO1, EC:1.14.14.18 |
| Swissprot | |
| Calculated MW | 33 kDa |
| Observed MW | 25 kDa |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Neuroscience, Cardiovascular, Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Metabolism |
| Conjugation | Unconjugated |
| Background | Heme Oxygenase (HO),also known as HMOX,is the rate limiting enzyme in the breakdown of heme into Biliverdin,CO,and iron. There are two major isoforms of this enzyme,HO-1 and HO-2. Both have similar enzymatic activity,however,HO-1 is rapidly inducible,while HO-2 is constitutively expressed. Inducers of HO-1 include cell stressors such as oxidative stress,infection,hypoxia,and cytotoxic agents. The reaction products generated by HO-1 activity are biologically active,and the enzyme has a broad range of putative roles. For instance,Biliverdin is an antioxidant with cytoprotective and anti-inflammatory properties,and CO has the potential to suppress inflammation and apoptosis. Because of these activities,HO-1 has received much attention as a therapeutic target for a range of pathological processes. |
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