IL-12 p70 Polyclonal Antibody(Capture/Detector)
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- 宿主： Rabbit
- 反应性： Rat
- 应用性： ELISA Capture/Detector
| Verified Samples |
Verified Samples in ELISA: Recombinant Rat IL-12 p70 protein, Rat serum, Rat plasma |
| Dilution | ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Recombinant Rat IL-12 p70 protein expressed by Mammalian |
| Abbre | IL-12 p70 |
| Synonyms | IL-12A, IL12a, InterLeukin-12 subunit aLpha, Cytotoxic Lymphocyte maturation factor 35 kDa subunit (CLMF p35), IL-12 subunit p35, IL12b, IL12B, InterLeukin-12 subunit beta, Cytotoxic Lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Background | Heterodimerizes with Il12B to form the Il-12 cytokine or with EBI3/Il27B to form the Il-35 cytokine. Il-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses,induces the production of interferon-gamma (IFN-gamma),favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically,exerts its biological effects through a receptor composed of Il12R1 and Il12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn,recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes.As part of Il-35,plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine.Mediates biological events through unconventional receptors composed of Il12RB2 and gp130/Il6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4,which form a unique heterodimer that binds to distinct DNA sites. |
| PDMR100002 | Recombinant Rat Interleukin-12/IL-12 Protein (His Tag) | 100 μg , 20 μg |
